Abacus 2.0 Test Modules:
Precision & Bias
- 20 x 1 Model
- 5 x 4 Model
- 20 x 1 plus 5 x 3 Model
- n x 1 Model
- CLSI EP-15A3
Precision
- Simple
- 1-Run (CLSI EP5-A2)
- 2-Runs (CLSI EP5-A2)
Method Comparisons
- Method Comparison (CLSI EP09-A3)
- Multi-Instrument Comparison
- Bland-Altman Plot
- Semiquantitative Methods
- Qualitative - Known Diagnosis (CLSI EP12-A)
- Qualitative - Unknown Diagnosis (CLSI EP12-A)
- Qualitative - Three-Way (CLSI EP12-A)
Linearity
- Linearity (CLSI EP6-A)
- Linearity / Calibration Verification
Regression
- Linear (weighted/unweighted)
- Deming (known/unknown error)
- Passing Bablok
- Polynomial (2nd to 6th degree)
Analysis of Variance(ANOVA)
- ANOVA-One-Way
- ANOVA-Two-Way
- Kruskal-Wallis
- Friedman
Analytical Sensitivity
- Limit of Detection - LoD (CLSI EP17-A)
- Limit of Detection - LoD (DIN32645)
- Limit of Quantitation - LoQ (CLSI EP17-A)
- PCR Methods
Analytical Specificity
- Interference - Fixed Conc. (CLSI EP07-A)
- Interference - Variable Conc. (CLSI EP07-A)
Quality Control
- Internal Quality Assurance (RiliBÄK)
- Intra-Laboratory Error Limits (RiliBÄK)
- Measurement Uncertainty
- Inter-Laboratory Comparisons
Descriptive Statistics
- Box-Whisker Plot
- Histogram
Correlation
- Pearson Correlation
- Spearman Correlation
- Kendall's Tau
Comparison of Means
- t-Test (One-Sample)
- t-Test (Paired Samples)
- t-Test (Unpaired Samples)
- Sign-Test (One-Sample Test)
- Wilcoxon Test
- Mann-Whitney Test
Contingency Tables
- Chi-Squared Test (2x2)
- McNemar Test (2x2)
- Cochran's Q-Test (kx2)
Reference Range (CLSI C28-A3c)
Stability Testing
Recovery
Carry-Over (normal/simple)
ROC Analysis
Two-Sample F-Test
Screenshots
Seamless integration with MS Excel
Abacus 2.0 adds 54 statistical modules to MS Excel's functions. All functions are comprehensively documented in the help file and working examples are available for each module.
Method comparison experiments
Results of bias estimation experiments are presented with a Bland-Altman difference plot and a Passing-Bablok regression plot, which is in line with recommendations from CLSI and international accreditation bodies.
Intuitive dialogs, simple data-entry
Intuitive handling, intelligent design, optimal productivity. Abacus 2.0 works with easy-to-use intuitive dialog forms, which include an auto-complete function, to speed up data-entry.
Reference range calculations
Calculate reference ranges with parametric, non-parametric, robust and bootstrap methods, adhering to CLSI and NACB recommendations. Perform box-cox-, log- or root-transformations and verify manufacturers' reference ranges.
Measurement uncertainty
Easily calculate measurement uncertainty, as required by ISO 15189 / 17025, using the Nordtest or DEV-A04 method.
Precision & Bias according to CLSI
Simple and quick estimation of precision and bias according to CLSI recommendations (CLSI EP15-A3). Have Abacus 2.0 automatically calculate allowable error limits, using the most current algorithms.
Stability estimates
Single or multiple measurements: Abacus 2.0 simplifies the interpretation and interpolation of stability measurement results.
Passing-Bablok Regression
Analyze method comparison data with a Passing-Bablok regression analysis, including residual- and CUSUM plots.
References
Siemens Healthcare
We use Abacus for analysis of internal, as well as client data. Apart from its simple, intuitive handling, the program boasts an impressive amount of statistical functions, that cover much of what can be encountered during the dailiy routine within the laboratory. Moreover it makes allowance for national (RiliBÄK) as well as international standards (CLSI), which is a huge advantage not only for accredited laboratories and laboratories working internationally. On top of that, the package includes a comprehensive help function, which we use, among others, when preparing method validation experiments. In conclusion: Software created by users for users.
Andreas Ullrich, Support Manager
University Hospital Salzburg (SALK)
Our institute acquired Abacus as part of the preparations for the accreditation according to ISO 15189. Our goal was to carry out instrument- and method-comparisons, to establish target values and to perform method-validations (single-run precision, stability testing, linearity testing etc.) or even calculate reference ranges, in a standardized fashion and according to current guidelines. Abacus provided an enormous help with this and today we would not know what we would do without it.
Dr. Janne Cadamuro, Senior Physician, University Institute of Medical and Chemical Laboratory Diagnostics, Salzburg
Provincial Government, Department of Health, Lower Austria
I have been using Abacus ever since my training as a Chemical Pathologist at the University of Graz. It is unsurpassed in its class, especially in terms of ease-of-use, which makes it suitable and highly recommended for every-day-use. Of course there are more comprehensive and more powerful programs available on the market, however these usually require long familiarization periods, resulting in substantially higher costs. From my point of view, I can recommend the tool to anyone, who has to work with medical statistics, especially in the field of clinical chemistry. As a long-standing emergency physician at the University Clinic of Graz, a suitable analogy comes to mind: Not every patient, who requires an emergency physician, also requires a full anaesthetic on-site - usually less is sufficient. This is similar with statistical software.
Dr. Gerhard Höbarth, Public Health Officer
Institute for Laboratory Diagnostics Südharz Clinic Nordhausen gGmbH
We are very happy with Abacus. It is used mainly for method comparisons. Due to its relative ease-of-use, my colleagues manage very well with the program. The graphical representations are always well received at inspections. I am happy, we have this program.
Petra Willomitzer, Quality Manager
Bioscientia Institute for Medical Diagnostics GmbH
We have been using Abacus in all our regional laboratories for a number of years. Owing to its integration into the familiar Excel environment, the software is easy to use, generally resulting in very short familiarization periods, also for staff less adept at statistics. The spectrum of testing protocols and statistical functions, combined with the fact that the program is validated according to current GAMP-5 guidelines, enables virtually unlimited use in all departments, including our Clinical Trials department. Added to this is the standardized presentation of the results with graphs and tables, which have passed all internal and external audits (accreditation, Bureau of Standards, clinical trials sponsors) in our laboratories so far. By implementing this software, we were able to not only save a considerable amount of time, but also to standardize method-validations and various quality control processes in our laboratories. In light of our consistently positive experiences, we can recommend Abacus without reservations.
PD Dr. med. Markus Nauck, CEO and Medical Director
Medical Laboratory Limbach Hannover
Easy-to-use and easy-to-understand software, comprehensive help file. A highly user-friendly software, also for people with limited Excel skills, as much is self-explanatory and calculations are carried out with simple clicks and predefined, but also freely editable criteria with a minimum amount of time-expenditure. Reports were used for internal, as well as external audits (inspection by the Occupational Safety and Health Inspectorate) and accepted in all instances. Although SOP documents must still be maintained for the accreditation, this can be done with considerably less effort. Abacus offers a variety of possibilites for method-validations (quantitative, qualitative etc.), allowing us to use it for all of our test systems. It also includes good graphical presentations and the possibility to add comments to reports. Compared to our previous system, we estimate a time saving of at least 70%, and now have a standardized process for all departments using Abacus.
Marlies Bode & Uta Zinngrebe (Medical Technologists)
Transplant Center Cologne-Mehrheim
The Transplant Center Cologne has been successfully using the Excel-Adin "Abacus" routinely for a number of years. We also use the software for quality control purposes in our nephrology laboratory for the evaluation and documentation of mandatory quality control testing. Apart from that the software also offers a multitude of statistical functions, which we use for scientific questions and to validate new methods. The clear layout of individual elements, combined with the comprehensive integrated help file, allows for intuitive handling at a fair price. We appreciate the continuous development of the program and the possibility to have individual solutions integrated. In summary, the program is a valuable help, which we would not like to miss anymore.
OA Dr. med. Wolfgang Arns, Director Transplant Center
Licenses
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- License for 10 PC's
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- Site License
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* All prices exclude VAT
Prices for perpetual licenses can be found here.
Webinars
- Module 1 - Basic Method Validation
- Verification of Precision & Bias with CLSI EP15-A3 and 5x4 model
- Method comparisons with Passing-Bablok regression and Bland-Altman plots
- Multi-instrument comparisons
- Comparison of semiquantitative methods
- Comparison of qualitative methods
- Duration: approx. 3 hours
- Price: 850,00 € *
- Module 2 - Advanced method validation
- Linearity, confirmation of analytical measurement range
- Limit of detection / limit of quantitation
- Determination of reference ranges
- Stability measurements
- Carry-over
- Duration: approx. 3 hours
- Price: 850,00 € *
* All prices exclude VAT
About the author
Joachim Pum, MBChB, MMed, FC Path
After completing his medical studies in Pretoria/South Africa, Dr. Pum decided to specialize in Chemical Pathology. In 2002 he moved to Europe with his family, where he worked for Medical Research Laboratories International (later "PPD Global Central Labs"), a clinical trials laboratory in Brussels/Belgium. In 2003 his specialist degree was accepted by the Royal College of Pathologists in London and he was admitted to the Specialist Register of the General Medical Council. Shortly thereafter he took on the position of Laboratory Director / Associate Vice President MRL Europe / Chief Scientific Officer worldwide operations. In 2006 he decided to move to Germany with his family to join a local laboratory in Jena (Bioscientia), where he currently has the position of Medical Director.
Ever since he began working as a pathologist, he recognized the need for process optimization within the laboratory. His special focus has always been quality assurance and continuous quality improvement. His experience in the field, combined with his skills in software-programming, enabled him to to find unique solutions in this area. Apart from numerous publications he also completed his doctoral thesis on "Establishing a software program for internal quality assurance in the laboratory" in 2012, for which he was awarded "magna cum laude".
His long-standing commitment to quality assurance and quality improvement finally lead to the release of the award-winning software "Abacus 2.0", which is validated according to the GAMP-5 standard since 2015 and is marketed internationally by LABanalytics GmbH.
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